5-Chloronicotinic acid(CAS: 22620-27-5)

5-Chloronicotinic acid (CAS: 22620-27-5) is a crystalline solid with a molecular weight of approximately 143.57 g/mol. It has a solubility of about 12.8 g/100 mL in water at 20°C. This compound is moderately reactive, particularly towards nucleophilic substitution reactions. It is stable under normal conditions but should be stored in a dry, cool place to avoid hydrolysis.

5-Chloronicotinic acid (CAS: 22620-27-5) is typically synthesized by chlorination of nicotinic acid with thionyl chloride. The reaction is carried out in the presence of a solvent like dichloromethane, and a high yield is achieved. The reaction is selective and produces a pure product with good yield.

5-Chloronicotinic acid (CAS: 22620-27-5) is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly in the production of nicotinic acid derivatives used as antihyperglycemic agents. It also finds applications in the chemical industry, where it is used in the synthesis of dyes and in the development of sensors due to its ability to form coordination complexes.

When handling 5-Chloronicotinic acid (CAS: 22620-27-5), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area, preferably in a fume hood, to avoid inhalation. Spills should be cleaned up with caution, and proper safety data sheets (SDS) should be consulted for detailed instructions. Storage should be in a cool, dry place away from direct sunlight.