Compound Q&A
How is (2E)-3-(4-Fluorophenyl)acrylic acid (CAS: 459-32-5) typically synthesized?
Answer
(2E)-3-(4-Fluorophenyl)acrylic acid (CAS: 459-32-5) is typically synthesized via a two-step process. First, 4-fluorophenylacetonitrile is treated with an acid catalyst like sulfuric acid to form the nitrile acid. Then, the nitrile acid is reduced to the acid using a reductive amination process with hydrazine or a similar reducing agent. The overall reaction is selective and yields up to 90% of the desired product.
About
CAS No
459-32-5
English Name
(2E)-3-(4-Fluorophenyl)acrylic acid
Molecular Formula
C9H7FO2
Molecular Weight
166.15 g/mol
SMILES
C1=CC(=CC=C1C=CC(=O)O)F
InChIKey
ISMMYAZSUSYVQG-ZZXKWVIFSA-N
Last Updated: 2025-09-26 00:09
