Methyl D-valinate hydrochloride (1:1)(CAS: 21685-47-2)

Methyl D-valinate hydrochloride is a white crystalline solid with a molecular weight of approximately 258.26 g/mol. It is moderately soluble in water and ethanol. Chemically, it is relatively stable but reacts with strong bases to form the corresponding free base. It has a pKa of about 12. The compound has good solubility in organic solvents like ethyl acetate and acetone.

Methyl D-valinate hydrochloride is typically synthesized by reacting D-valine with methyl chloroformate in the presence of a catalytic amount of a tertiary amine like triethylamine. The reaction involves the formation of an ester followed by acidification with hydrochloric acid to form the hydrochloride salt. The yield is usually around 85-90%, and the reaction is known for its high selectivity.

Methyl D-valinate hydrochloride is used in several industries. It is primarily used in the pharmaceutical industry as a starting material for the synthesis of other compounds. It also finds applications in the polymer industry for the modification of polymer properties. Additionally, it is used in the food industry as a flavoring agent and in the sensor industry for the detection of specific compounds.

When handling Methyl D-valinate hydrochloride, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. It should be stored in a well-ventilated area and handled in a fume hood to minimize exposure. In case of a spill, it should be cleaned up using appropriate absorbent materials. For more detailed safety information, refer to the Material Safety Data Sheet (MSDS/SDS).