Methyl 1-acetyl-2-oxo-6-indolinecarboxylate(CAS: 676326-36-6)

Methyl 1-acetyl-2-oxo-6-indolinecarboxylate is a crystalline compound with a molecular weight of approximately 285.33 g/mol. It is slightly soluble in water but readily soluble in organic solvents such as dichloromethane. This compound is moderately reactive, particularly towards nucleophiles. It has a melting point of about 122-124°C and a density of around 1.21 g/cm³.

Methyl 1-acetyl-2-oxo-6-indolinecarboxylate can be synthesized through a multi-step process involving the reaction of 6-indole-3-carboxylic acid with acetic anhydride in the presence of a catalytic amount of p-toluenesulfonic acid. The yield is around 85%, and the method involves good selectivity and high purity of the product.

Methyl 1-acetyl-2-oxo-6-indolinecarboxylate is primarily used in the pharmaceutical industry for the synthesis of various bioactive compounds. It is also utilized in the research and development of new materials, particularly in polymer and sensor applications due to its unique chemical properties.

When handling Methyl 1-acetyl-2-oxo-6-indolinecarboxylate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work under a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbents, and the area should be well-ventilated. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.