Methyl 2,5-dibromonicotinate(CAS: 78686-82-5)

Methyl 2,5-dibromonicotinate (CAS: 78686-82-5) is a crystalline solid with a molecular weight of approximately 380.02 g/mol. It is sparingly soluble in water but dissolves easily in organic solvents like ethanol and acetone. This compound is highly reactive towards nucleophiles and electrophiles. It exhibits strong electrophilic bromine substituents which can undergo substitution reactions under various conditions.

Methyl 2,5-dibromonicotinate (CAS: 78686-82-5) is typically synthesized by the bromination of methyl nicotinate. This can be achieved using N-bromosuccinimide (NBS) in the presence of a radical initiator like benzoyl peroxide. The reaction yields a mixture of isomers which can be separated by recrystallization. The yield is generally around 70-80%, depending on the purity of starting materials and reaction conditions.

Methyl 2,5-dibromonicotinate (CAS: 78686-82-5) is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also finds application in the production of functionalized organic compounds for use in sensors and semiconductors. Its reactivity towards electrophiles makes it useful in these sectors for creating specific chemical functionalities.

Handling Methyl 2,5-dibromonicotinate (CAS: 78686-82-5) requires strict safety measures. Always wear personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work in a well-ventilated fume hood to minimize inhalation risk. Store the compound in a cool, dry place away from direct sunlight and heat sources. In case of a spill, immediately clean up using appropriate absorbents and follow standard chemical spill procedures. Always consult the SDS for detailed safety information.