(4-Nitrophenyl)boronic acid(CAS: 24067-17-2)

(4-Nitrophenyl)boronic acid is a white crystalline solid with a molecular weight of 232.07 g/mol. It has a solubility of 2.4 g/L in water and exhibits moderate solubility in organic solvents. It is a weak acid and is known for its reactivity in boronate ester formation and its use in Suzuki coupling reactions.

(4-Nitrophenyl)boronic acid is typically synthesized through the esterification of phenylboronic acid with nitric acid. The reaction is carried out under acidic conditions to convert the boronic acid to the nitrophenyl boronic acid. Catalysts such as sulfuric acid are often used to improve yield and selectivity.

(4-Nitrophenyl)boronic acid is used in various industries including pharmaceuticals, where it is used as a substrate in reactions such as Suzuki coupling for drug synthesis. It is also used in the polymer industry for the modification of polymers, and in the semiconductor industry for the production of electronic materials.

When handling (4-Nitrophenyl)boronic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid exposure to the air. Spills should be cleaned up carefully using appropriate chemicals, and the area should be thoroughly rinsed. Always refer to the Material Safety Data Sheet (MSDS) for specific handling instructions.