5-Bromo-2-chloro-3-methylpyridine(CAS: 29241-60-9)

5-Bromo-2-chloro-3-methylpyridine (CAS: 29241-60-9) is a crystalline solid with a molecular weight of approximately 218.02 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is relatively stable but can react with strong nucleophiles. It has a melting point of about 125-128°C and is a potential substrate in organic synthesis and pharmaceuticals.

5-Bromo-2-chloro-3-methylpyridine (CAS: 29241-60-9) is commonly synthesized via the halo substitution of 3-methylpyridine. This can be achieved using a Br2/FeCl3 mixture for bromination, followed by chlorination using PCl3 or PCl5. The reaction is typically performed under anhydrous conditions to avoid hydrolysis, with yields ranging from 60-85%.

5-Bromo-2-chloro-3-methylpyridine (CAS: 29241-60-9) is used in various industries. It is an important intermediate in the synthesis of pharmaceutical compounds, particularly in antiviral drugs. It also finds applications in the manufacture of certain polymers and as a reagent in organic chemistry research. Additionally, it can be used in sensor technology and semiconductor manufacturing due to its electronic properties.

When handling 5-Bromo-2-chloro-3-methylpyridine (CAS: 29241-60-9), it is crucial to wear proper personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed emergency procedures and storage recommendations.