2-Oxo-1,2-dihydro-4-quinazolinecarboxylic acid(CAS: 99066-77-0)

2-Oxo-1,2-dihydro-4-quinazolinecarboxylic acid has a crystalline form with a molecular weight of approximately 216.21 g/mol. It is slightly soluble in water and more soluble in organic solvents. The compound is moderately reactive and susceptible to hydrolysis under acidic conditions. It has a pKa of about 4.5, indicating its acidic nature.

2-Oxo-1,2-dihydro-4-quinazolinecarboxylic acid is typically synthesized through the condensation of 4-aminobenzoyl chloride with 1,3-dicarbonyl compounds such as trimesic acid. The reaction involves the use of a catalyst like tin(II) chloride to enhance the yield. The process is selective and yields up to 85% of 2-oxo-1,2-dihydro-4-quinazolinecarboxylic acid.

2-Oxo-1,2-dihydro-4-quinazolinecarboxylic acid is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry for the modification of materials. Additionally, it has applications in the development of sensors and semiconductors due to its unique chemical properties.

When handling 2-Oxo-1,2-dihydro-4-quinazolinecarboxylic acid, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a laboratory coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up with appropriate absorbents, and the material safety data sheet (MSDS) should be readily available for reference.