Bexarotene(CAS: 153559-49-0)

Bexarotene is a crystalline compound with a molecular weight of approximately 322.32 g/mol. It has a low solubility in water but is soluble in organic solvents like chloroform and methanol. Bexarotene is relatively stable under normal conditions but can react with strong oxidizing agents. It is also known for its poor reactivity with common laboratory reagents.

Bexarotene is typically synthesized through a multistep process involving acylation of a primary alcohol followed by oxidation and reduction. Commonly used catalysts include molecular sieves and various transition metals. The overall yield is around 50%, with good selectivity towards the desired product.

Bexarotene is primarily used in the pharmaceutical industry due to its anti-tumor properties. It has applications in treating cutaneous T-cell lymphoma. Additionally, it can be used in research and development for studying retinoid signaling pathways and gene expression regulation.

When handling Bexarotene, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat is essential. Work should be conducted in a well-ventilated area or fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal information.