4,6-Dichloro-5-nitropyrimidine(CAS: 4316-93-2)

4,6-Dichloro-5-nitropyrimidine is a solid with a crystalline form. Its molecular weight is approximately 230.03 g/mol. It has low water solubility but is soluble in common organic solvents like ethanol and acetone. The compound is known for its high reactivity, particularly towards nucleophilic substitution reactions.

4,6-Dichloro-5-nitropyrimidine can be synthesized via a multi-step process involving the nitration of 5-chloropyrimidine followed by chlorination. Commonly used catalysts include sulfuric acid, and the reaction is carried out in a suitable solvent like acetic acid. The yield is typically around 70-80%, with high selectivity towards the desired product.

4,6-Dichloro-5-nitropyrimidine is used primarily in the pharmaceutical industry for the synthesis of certain drugs. It is also applied in the agricultural sector as a herbicide intermediate. Additionally, it has potential applications in the polymer and semiconductor industries for specific chemical processes.

When handling 4,6-Dichloro-5-nitropyrimidine, it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.