N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine hydrochloride(CAS: 184475-55-6)

N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine hydrochloride is a crystalline compound with a molecular weight of approximately 511.82 g/mol. It has low solubility in water but good solubility in organic solvents like DMSO and ethanol. This compound exhibits moderate reactivity towards nucleophiles and can undergo substitution reactions. It is stable under normal conditions but should be stored away from strong acids and bases.

N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine hydrochloride is synthesized through a multi-step process involving alkylation followed by nucleophilic substitution reactions. Commonly, the synthesis involves protecting groups for functional groups, followed by the introduction of the morpholine moiety via a nucleophilic addition, and finally the amine formation and hydrochloride salt formation. The reaction typically achieves a yield of 70-80% under mild conditions.

N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine hydrochloride is primarily used in the pharmaceutical industry for its potential as a drug candidate. It may also find applications in the polymer industry for the development of novel materials with specific properties. Its unique chemical structure makes it suitable for research in sensor and semiconductor technologies, although its application in these fields is less common compared to pharmaceuticals.

When handling N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine hydrochloride, it is crucial to use personal protective equipment (PPE) such as gloves and safety goggles. The compound should be stored in a dry, well-ventilated area away from strong acids and bases. In case of a spill, it should be cleaned up using appropriate procedures, and the site should be decontaminated. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.