How is N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine hydrochloride (CAS: 184475-55-6) typically synthesized?

N-(3-chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine hydrochloride is synthesized through a multi-step process involving alkylation followed by nucleophilic substitution reactions. Commonly, the synthesis involves protecting groups for functional groups, followed by the introduction of the morpholine moiety via a nucleophilic addition, and finally the amine formation and hydrochloride salt formation. The reaction typically achieves a yield of 70-80% under mild conditions.