4-Bromo-1,3-dihydro-2H-indol-2-one(CAS: 99365-48-7)

4-Bromo-1,3-dihydro-2H-indol-2-one (CAS: 99365-48-7) is a crystalline solid with a molecular weight of approximately 227.03 g/mol. It has a low solubility in water but is more soluble in polar organic solvents like dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). This compound is known for its good reactivity towards nucleophiles and has moderate stability under acidic and basic conditions.

4-Bromo-1,3-dihydro-2H-indol-2-one is commonly synthesized through the bromination of indole-2-one. This process involves the use of bromine in the presence of a base like sodium hydroxide. The reaction is typically carried out in a polar solvent such as dimethyl sulfoxide (DMSO) and yields the target compound in moderate to good selectivity and yield.

4-Bromo-1,3-dihydro-2H-indol-2-one (CAS: 99365-48-7) is primarily used in the pharmaceutical industry for the synthesis of novel drug candidates. It also finds applications in the sensor industry due to its specific reactivity and in the semiconductor industry as an intermediate for the development of advanced materials.

When handling 4-Bromo-1,3-dihydro-2H-indol-2-one (CAS: 99365-48-7), it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be neutralized with a suitable base or acid before cleaning up. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.