7-Deaza-2'-dG(CAS: 86392-75-8)

7-Deaza-2'-dG (CAS: 86392-75-8) is a nucleoside analog. It is a white or off-white crystalline solid with a molecular weight of approximately 241.21 g/mol. Its solubility in water is 0.1 g/L at 25°C. Chemically, it is less reactive than its natural counterpart, 2'-deoxyguanosine. It is stable in the solid state and in aqueous solutions at neutral pH but should be protected from strong acids and bases.

7-Deaza-2'-dG can be synthesized via a multistep process where the 7-deazapyrimidine ring is built from precursors such as 6-azauridine. Common methods include nucleophilic substitution and condensation reactions. The key steps involve the installation of the 2'-hydroxyl group and the 7-deazapyrimidine core. Catalysts like organic acids or bases may be used, and the overall yield typically ranges from 60% to 80%. High selectivity for the desired product is achieved through careful control of reaction conditions.

7-Deaza-2'-dG (CAS: 86392-75-8) finds application in the pharmaceutical industry, particularly in the development of antiviral drugs and as a research tool in molecular biology. It is also used in the synthesis of nucleic acid analogs for sensors and in the preparation of semiconducting materials for electronic devices. Its ability to modify nucleoside structures makes it valuable in polymer science for the development of novel materials.

When handling 7-Deaza-2'-dG (CAS: 86392-75-8), it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. It is water-soluble and can be harmful if ingested or inhaled. Work must be done in a well-ventilated area or a fume hood. In case of a spill, immediately clean up with care to avoid skin contact. Always refer to the safety data sheet (SDS) for detailed information on proper handling and storage procedures.