Benzyl 3-fluoro-4-oxo-1-piperidinecarboxylate(CAS: 845256-59-9)

Benzyl 3-fluoro-4-oxo-1-piperidinecarboxylate (CAS: 845256-59-9) is a crystalline solid with a molecular weight of approximately 265.26 g/mol. It has poor water solubility but good solubility in organic solvents such as ethanol and dichloromethane. The compound is relatively stable but may react with strong bases to form 3-fluoro-4-hydroxy-1-piperidinecarboxylic acid. It is not flammable but can release toxic fumes upon thermal decomposition.

Benzyl 3-fluoro-4-oxo-1-piperidinecarboxylate (CAS: 845256-59-9) can be synthesized via a multistep reaction involving the protection of a piperidine ring, introduction of a fluoro group, and subsequent deprotection. Commonly used catalysts and reagents include trifluoroacetic acid (TFA) and triflic anhydride. The reaction is selective and yields >90% of the desired product.

Benzyl 3-fluoro-4-oxo-1-piperidinecarboxylate (CAS: 845256-59-9) is primarily used in pharmaceuticals for the synthesis of various drug intermediates. It is also utilized in the development of polymers, sensors, and semiconductors due to its unique chemical properties.

When handling Benzyl 3-fluoro-4-oxo-1-piperidinecarboxylate (CAS: 845256-59-9), wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Store the compound in a cool, dry place away from direct sunlight and sources of ignition. In case of spill, use a fume hood and follow standard spill procedures. Always consult the Safety Data Sheet (SDS) for detailed handling and storage information.