(2S)-Amino(cyclopropyl)acetic acid(CAS: 49606-99-7)

(2S)-Amino(cyclopropyl)acetic acid is a colorless crystalline solid with a molecular weight of approximately 125.09 g/mol. It has a pKa value of around 2.5 and is slightly soluble in water. This compound is known for its reactivity, particularly in forming amide and ester bonds. It is often used as a building block in organic synthesis due to its unique cyclopropyl group and amino functionality.

(2S)-Amino(cyclopropyl)acetic acid can be synthesized via the Wittig reaction starting from a cyclopropyl methyl ketone and a phosphonium ylide. Alternatively, it can be prepared through the Sonogashira coupling of a cyclopropyl aryl iodide with propargylamine. These methods provide good yields and high purity, making (2S)-Amino(cyclopropyl)acetic acid a valuable intermediate in organic synthesis.

(2S)-Amino(cyclopropyl)acetic acid is predominantly used in the pharmaceutical industry as a chiral building block for the synthesis of drugs. It is also utilized in the polymer industry for the production of biodegradable polymers, and in the sensor industry for developing biosensors. Its unique structure and functional groups make it a versatile compound in various applications.

When handling (2S)-Amino(cyclopropyl)acetic acid, it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of dust or vapors. Spills should be cleaned up using appropriate absorbent materials, and proper disposal procedures should be followed as outlined in the Safety Data Sheet (SDS).