2-(4-Aminophenyl)-N-methylethanesulfonamide(CAS: 98623-16-6)

2-(4-Aminophenyl)-N-methylethanesulfonamide (CAS: 98623-16-6) is a white crystalline solid with a molecular weight of approximately 217.26 g/mol. It has a pKa of about 8.0 and is poorly soluble in water but soluble in organic solvents like ethanol and acetone. It is relatively stable but can undergo hydrolysis in basic conditions. This compound exhibits good reactivity in substitution reactions, particularly with nucleophiles.

2-(4-Aminophenyl)-N-methylethanesulfonamide (CAS: 98623-16-6) can be synthesized via a multistep process involving the reaction of 4-aminophenol with methanesulfonyl chloride in the presence of a base like sodium hydroxide. The key steps include the formation of the methanesulfonate ester followed by the reduction of the nitro group to an amine. The yield is typically around 70-80%, and the method requires appropriate handling of reagents and solvents.

2-(4-Aminophenyl)-N-methylethanesulfonamide (CAS: 98623-16-6) finds applications in the pharmaceutical industry, particularly in the synthesis of intermediates for drugs. It is also used in polymer chemistry for modifying the properties of polymers and in the development of new materials. Additionally, it is employed in the production of sensors and semiconductors due to its unique chemical properties.

When handling 2-(4-Aminophenyl)-N-methylethanesulfonamide (CAS: 98623-16-6), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to avoid inhalation of dust or vapors. Spills should be managed by using appropriate absorbent materials and disposing of them according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.