3-[(E)-2-(4-Hydroxyphenyl)vinyl]-5-methoxyphenol(CAS: 42438-89-1)

3-[(E)-2-(4-Hydroxyphenyl)vinyl]-5-methoxyphenol (CAS: 42438-89-1) is a crystalline solid with a molecular weight of approximately 262.28 g/mol. Its solubility in water is low (1.5 g/L at 25°C), and it is moderately soluble in common organic solvents like methanol and ethanol. This compound exhibits good reactivity towards electrophilic substitution due to the presence of the phenolic hydroxyl group and the methoxy group.

3-[(E)-2-(4-Hydroxyphenyl)vinyl]-5-methoxyphenol (CAS: 42438-89-1) is typically synthesized through a series of reactions involving coupling of a vinyl bromide with a 4-hydroxybenzophenone derivative followed by methylation. This process often requires the use of Lewis acids and mild heating to promote the coupling reaction. The overall yield is around 70%, with high selectivity for the desired product.

3-[(E)-2-(4-Hydroxyphenyl)vinyl]-5-methoxyphenol (CAS: 42438-89-1) is primarily used in the pharmaceutical industry for its potential as an active pharmaceutical ingredient (API) due to its antioxidant and anti-inflammatory properties. It also finds applications in the manufacturing of sensors and as a photostabilizer in polymers.

When handling 3-[(E)-2-(4-Hydroxyphenyl)vinyl]-5-methoxyphenol (CAS: 42438-89-1), it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Proper storage should be in a cool, dry place away from direct sunlight. In case of spills, immediately clean up with appropriate absorbents and follow safety data sheet (SDS) guidelines for disposal.