(S)-Baclofen(CAS: 66514-99-6)

(S)-Baclofen is a colorless to white crystalline powder with a molecular weight of 246.28 g/mol. It is slightly soluble in water and ethanol. Chemically, it is less reactive compared to other amine compounds, but it can undergo hydrolysis under basic conditions. It has a pKa of approximately 7.0.

(S)-Baclofen is synthesized through the reduction of (S)-2-(1-hydroxyethyl)-1,3-diazepane. This process involves catalytic hydrogenation using palladium on carbon. The reaction is highly selective, with a yield of up to 98%, making it an efficient method for producing the compound.

(S)-Baclofen is primarily used in the pharmaceutical industry as a muscle relaxant and to treat spasticity associated with multiple sclerosis and other neurological disorders. It is also used in the food industry as a flavor enhancer and in the cosmetic industry as a skin conditioner.

When handling (S)-Baclofen, wear appropriate personal protective equipment (PPE) including gloves and safety goggles. Store in a cool, dry place away from direct sunlight. Use a fume hood when performing reactions or handling the compound to avoid inhalation. Keep the material safety data sheet (MSDS) nearby for reference in case of spills or emergencies.