Transport phenomena in solid phase synthesis supported by cross-linked polymer beads
Literature Information
Mathias Kraume, José Danglad-Flores
Solid phase synthesis (SPS) is a powerful tool for synthesizing oligomers, especially peptides, nucleic acids, and glycans. Since Merrifield developed solid phase peptide synthesis in 1963, organic chemistry and analytics have seen major advances. The need to optimize the process regarding cost, time, and energy consumption has renewed the research on previously overlooked transport phenomena. Here, we summarize the current understanding of momentum, heat, and mass transport in SPS reactors, highlighting the progress and identifying the urgent questions to be addressed.
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Source Journal
Reaction Chemistry & Engineering

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.













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![1-{3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl}-2,3-dihydroxy-1-propanone structure 1-{3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl}-2,3-dihydroxy-1-propanone structure](https://static.chemtradehub.com/structs/122/1226872-27-0-e037.webp)