Molecular clips with spatially proximal urea residues for efficient transmembrane co-transport of H+/Cl− ions

Literature Information

Publication Date 2023-11-29
DOI 10.1039/D3OB01431B
Impact Factor 3.876
Authors

Nyaya Prakash Pradhan, Kavthekar Rupesh Namdev, Aasheesh Srivastava


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Abstract

We report the design of bis(urea) functionalized amphiphilic molecular clips viz. 1a–1e to achieve efficient transmembrane co-transport of H+/Cl− ions. The most promising molecule 1a demonstrated a low nanomolar EC50 value (6.96 nM) to co-transport H+/Cl− ions via a carrier-mediated pathway and showed selective toxicity against cancerous HeLa cells as a result.

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
CiteScore: 3.4
Self-citation Rate: 10.3%
Articles per Year: 1041

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.

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