Nickel-catalyzed regioselective hydrogen isotope exchange accelerated by 2-pyridones

Literature Information

Publication Date 2023-11-27
DOI 10.1039/D3CC05257E
Impact Factor 6.222
Authors

Zhi-Jiang Jiang, Erxun Hu, Jian-Fei Bai, Bencan Tang


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Abstract

A nickel-catalyzed hydrogen isotope exchange has been developed with acetone-d6 as the deuterium source. The reaction showed an improved kinetic feature of H/D exchange under the assistance of 2-pyridones, efficiently affording regioselective labeled aryl and alkyl carboxamides.

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