Cascade radical cyclization on 3-propargyl-2-alkenyl indole gives stereoselective access to cyclohepta[b]indole over carbazole
Literature Information
Santosh J. Gharpure, Sanyog Kumari
A protecting group-dependent diastereoselective synthesis of cyclohepta[b]indole over carbazole derivatives is developed. This strategy involves a regioselective 6-exo-trig radical cyclization-cyclopropanation-ring expansion cascade of 3-propargyl-2-alkenyl indole. The cascade radical cyclization was also performed on indole derivatives possessing alkyne, acrylate and vinylogous carbamate moieties, which delivered pyridocarbazole giving credence to the mechanistic hypothesis. Furthermore, cyclohepta[b]indole could be selectively converted to sulfone and sulfoxide as well as benzoazulenoindole via intramolecular Friedel–Crafts acylation.
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