One-pot two-step radioiodination based on copper-mediated iododeboronation and azide–alkyne cycloaddition reaction

Literature Information

Publication Date 2023-12-18
DOI 10.1039/D3CC04787C
Impact Factor 6.222
Authors

Yuto Kondo, Ryota Chisaka, Yasunao Hattori, Hidekazu Kawashima, Hiroyuki Yasui


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Abstract

This methodology demonstrates the ability to sequentially regulate copper-mediated radioiododeboronation and an azide–alkyne cycloaddition reaction, which facilitates the continuous incorporation of reagents into the reaction system and mediates the integration of the purification steps into the final process. Additionally, this reaction is suited to be conducted under mild conditions and yields target compounds through potent radiochemical conversions.

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