Solid solution polymorphs afford two highly soluble co-drug forms of tolbutamide and chlorpropamide

Literature Information

Publication Date 2023-11-10
DOI 10.1039/D3CC04725C
Impact Factor 6.222
Authors

Enrico Spoletti, Vivek Verma, Chiara Cappuccino, Matteo Lusi


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Abstract

The search for solid solutions of class-two insulin secretagogues, tolbutamide and chlorpropamide, reveals a rare case of monotropic polymorphism for the mixed crystals. At any stoichiometry, two crystal forms are isolated that are kinetically stable at room temperature from a few months to over a year. Dissolution tests certify the solubility advantage of the solid solutions over the pure drugs as well as their physical mixture, suggesting a potential application as a highly soluble co-drug formulation.

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