Leveraging cascade alkynyl Prins cyclization towards the stereoselective synthesis of spiro-furan quinazolinone scaffolds

Literature Information

Publication Date 2023-11-08
DOI 10.1039/D3CC04464E
Impact Factor 6.222
Authors

Subhamoy Biswas, Sudip Shit, Bipin Kumar Behera, Archana Kumari Sahu, Anil K. Saikia


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Abstract

A TfOH-promoted, metal-free protocol has been unveiled for the synthesis of spiro-furan quinazolinones employing alkynol urea derivatives utilizing alkynyl Prins cyclization reaction. This methodology produces highly functionalized spiro-heterocycles in excellent yields with exclusive E-selectivity under ambient conditions. Furthermore, late-stage modifications incorporate bromide and acetyl functionalities into the synthesized spiro-heterocycles.

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