Visible-light-mediated synthesis of non-anomeric S-aryl glycosides via a photoactive electron-donor–acceptor complex

Literature Information

Publication Date 2023-10-27
DOI 10.1039/D3CC03474G
Impact Factor 6.222
Authors

Le Zhang, Shiyun He, Jinyu Hou, Meiling Ye, Jian Chen, Guanghui Lv, Tianle Huang, Zhongzhen Yang, Yong Wu


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Abstract

A visible-light-mediated glycosylation reaction between glycosyl redox-active esters and disulfides has been reported, through which a series of S-aryl glycosides were obtained in good yields with satisfactory stereoselectivity. The preliminary mechanistic studies revealed that this transformation proceeded via an EDA complex. Moreover, the potential application value was demonstrated in the late-stage functionalisation of drug molecules and a gram-scale experiment.

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