A novel multicomponent quadruple/double quadruple domino reaction: highly efficient synthesis of polyheterocyclic architectures

Literature Information

Publication Date 2018-12-12
DOI 10.1039/C8OB02970A
Impact Factor 3.876
Authors

Manickam Bakthadoss, Srinivasan Jayakumar, Selvakumar Raman, Anthonisamy Devaraj, Duddu S. Sharada


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Abstract

A novel multicomponent quadruple domino reaction (MCQDR) for the assembly of structurally complex molecular architectures via the formation of three rings and three contiguous stereogenic centers has been accomplished with high regio- and diastereoselectivity. Solvents, catalysts and work-up were not required to obtain the target molecules. In addition, this new protocol is also extended for the multicomponent double quadruple domino reaction (MCDQDR) to create novel polyheterocyclic architectures in an orthogonal manner.

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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry
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