An ambient pressure, direct hydrogenation of ketones

Literature Information

Publication Date 2023-06-09
DOI 10.1039/D3CC01014G
Impact Factor 6.222
Authors

Long Zhang, Zhiyao Lu, Andrew R. Rander, Travis J. Williams


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Abstract

We report two bifunctional (pyridyl)carbene-iridium(I) complexes that catalyze ketone and aldehyde hydrogenation at ambient pressure. Aryl, heteroaryl, and alkyl groups are demonstrated, and mechanistic studies reveal an unusual polarization effect in which the rate is dependant of proton, rather than hydride, transfer. This method introduces a convenient, waste-free alternative to traditional borohydride and aluminum hydride reagents.

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Chemical Communications

Chemical Communications
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