1,3(2H,4H)-Isoquinolinedione, 7-amino-4,4-dimethyl-
CAS Number:
14576-22-8
Molecular Formula:
C11H12N2O2
In-source fragmentation of nucleosides in electrospray ionization towards more sensitive and accurate nucleoside analysis
Literature Information
Publication Date
2023-02-21
DOI
10.1039/D3AN00047H
Impact Factor
4.616
Authors
Yu-Nan Chen, Xu-Yang Shen, Yue Yu, Chen-Yu Xue, Ying-Lin Zhou, Xin-Xiang Zhang
View Original
Abstract
Nucleosides have been found to suffer in-source fragmentation (ISF) in electrospray ionization mass spectrometry, which leads to reduced sensitivity and ambiguous identification. In this work, a combination of theoretical calculations and nuclear magnetic resonance analysis revealed the key role of protonation at N3 near the glycosidic bond during ISF. Therefore, an ultrasensitive liquid chromatography-tandem mass spectrometry system for 5-formylcytosine detection was developed with 300 fold signal enhancement. Also, we established a MS1-only platform for nucleoside profiling and successfully identified sixteen nucleosides in the total RNA of MCF-7 cells. Taking ISF into account, we can realize analysis with higher sensitivity and less ambiguity, not only for nucleosides, but for other molecules with similar protonation and fragmentation behaviors.
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Source Journal
Analyst
CiteScore:
7.8
Self-citation Rate:
5.6%
Articles per Year:
653
Analyst publishes analytical and bioanalytical research that reports premier fundamental discoveries and inventions, and the applications of those discoveries, unconfined by traditional discipline barriers.
Recommended Compounds
![S-[2,3-Bis(palmitoyloxy)propyl]-N-[(9H-fluoren-9-ylmethoxy)(hydroxy)methylene]cysteine structure](https://static.chemtradehub.com/structs/210/210532-98-2-f6a7.webp "S-[2,3-Bis(palmitoyloxy)propyl]-N-[(9H-fluoren-9-ylmethoxy)(hydroxy)methylene]cysteine structure")
S-[2,3-Bis(palmitoyloxy)propyl]-N-[(9H-fluoren-9-ylmethoxy)(hydroxy)methylene]cysteine
CAS Number:
210532-98-2
Molecular Formula:
C53H83NO8S
2,2-dideuterio-2-(3,4,5,6-tetradeuterio-2-pyridyl)acetic acid;hydrochloride
CAS Number:
1329799-67-8
Molecular Formula:
C7H2ClD6NO2
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