Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients
Literature Information
Publication Date
2021-12-30
DOI
10.1039/D1RE00483B
Impact Factor
4.239
Authors
Cloudius R. Sagandira, Sinazo Nqeketo, Kanyisile Mhlana, Thembela Sonti, Sibongiseni Gaqa, Paul Watts
View Original
Abstract
Continuous flow chemistry has opened a new paradigm in both the laboratory and pharmaceutical industry. This review details the recently reported literature on continuous multistep telescoped synthesis of active pharmaceutical ingredients (APIs), inline flow downstream processing, in-process monitoring by process analytical technology (PAT) in flow, flow automation and artificial intelligence (AI) and robotics. We envisage that the integration of all these techniques can ensure an ‘ideal’ smart and efficient 21st century API chemical process that dramatically improves efficiency, agility, quality and flexibility in the manufacturing of pharmaceuticals.
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Source Journal
Reaction Chemistry & Engineering
CiteScore:
0
Self-citation Rate:
8.8%
Articles per Year:
284
Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.
Recommended Compounds
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[(2R)-6,6-Dimethyl-2-morpholinyl]methanol hydrochloride (1:1)
CAS Number:
1416444-88-6
Molecular Formula:
C7H16ClNO2
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CAS Number:
1020719-57-6
Molecular Formula:
C22H18D5ClN2O2
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