A continuous flow process for biaryls based on sequential Suzuki–Miyaura coupling and supercritical carbon dioxide extraction
Literature Information
Tomohiro Ichitsuka, Tatsuya Fujii, Marina Kobune, Takashi Makino, Shin-ichiro Kawasaki
We report a continuous flow process for biaryls consisting of a packed-bed reactor and a rapid extraction system. Continuous extraction with supercritical carbon dioxide (scCO2) was applied to a Suzuki–Miyaura coupling reaction mixture, which is typically challenging to connect with a continuous purification system. The flow synthesis module was optimized based on kinetic studies and yielded an aqueous ethanol solution of the target biaryls in quantitative yield; subsequently, continuous extraction with scCO2 to separate the biaryls and co-produced salts was carried out. This continuous process gave the desired biaryls in high yields and purities with almost no salts.
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Source Journal
Reaction Chemistry & Engineering

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.














