Development of a high intensity parallel photoreactor for high throughput screening

Literature Information

Publication Date 2021-11-17
DOI 10.1039/D1RE00317H
Impact Factor 4.239
Authors

Ning Qi, Michael K. Wismer, Donald V. Conway, Shane W. Krska, Spencer D. Dreher, Shishi Lin


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Abstract

We report the development of a high intensity photoreactor that enables high throughput screening of up to 1536 reactions on nanomole scales in parallel. The increased photon flux provided by this new reactor compared to previous parallel reactor designs enables high performance for reactions that are sensitive to light intensity. In addition, the uniformity of illumination and efficient heat removal of this reactor allow for the systematic investigation of the complex interplay between parameters such as light intensity, catalyst loading and reaction stoichiometry on nanomole scale. The ability to run hundreds or thousands of unique photochemistry experiments under highly controlled conditions also provides a standardized platform for screening and data gathering for informatics. Finally, the reactor allows for the successful reproduction of screening hits at medicinal chemistry relevant scales.

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Source Journal

Reaction Chemistry & Engineering

Reaction Chemistry & Engineering
CiteScore: 0
Self-citation Rate: 8.8%
Articles per Year: 284

Reaction Chemistry & Engineering is an interdisciplinary journal reporting cutting-edge research focused on enhancing the understanding and efficiency of reactions. Reaction engineering leverages the interface where fundamental molecular chemistry meets chemical engineering and technology. Challenges in chemistry can be overcome by the application of new technologies, while engineers may find improved solutions for process development from the latest developments in reaction chemistry. Reaction Chemistry & Engineering is a unique forum for researchers whose interests span the broad areas of chemical engineering and chemical sciences to come together in solving problems of importance to wider society. All papers should be written to be approachable by readers across the engineering and chemical sciences. Papers that consider multiple scales, from the laboratory up to and including plant scale, are particularly encouraged.

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