Synthesis of amidines via iron-catalyzed dearomative amination of β-naphthols with oxadiazolones

Literature Information

Publication Date 2021-11-30
DOI 10.1039/D1QO01687C
Impact Factor 5.281
Authors

Yan-Hui Fan, Xiao-Yu Guan, Wen-Pei Li, Cheng-Zhou Lin, De-Xian Bing, Mei-Zhi Sun, Guo Cheng, Jing Cao, Jun-Jie Chen, Qing-Hai Deng


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Abstract

An iron-catalyzed dearomative amination of β-naphthols via a nitrene-transfer process has been developed. Oxadiazolones, which have rarely been applied for the synthesis of amidines, are used as the nitrene source. A variety of amidines bearing β-naphthalenone moieties were generated smoothly in good to high yields (up to 98%) in the presence of 1.5 equivalents of tetrabutylammonium bromide, which was added as an essential additive.

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