Design of chiral ferrocenylphosphine-spiro phosphonamidite ligands for ruthenium-catalyzed highly enantioselective coupling of 1,2-diols with amines

Literature Information

Publication Date 2021-11-03
DOI 10.1039/D1QO01443A
Impact Factor 5.281
Authors

Xiao Yi, Yirui Chen, An Huang, Dingguo Song, Jiaying He, Fei Ling, Weihui Zhong


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Abstract

A series of chiral ferrocene-backbone phosphines-spiro phosphonamidite ligands was developed for ruthenium-catalyzed enantioselective access to a broad range of β-amino alcohols from 1,2-diols and amines via the borrowing-hydrogen prciniple. Up to >99% ee with a broad substrate scope was attained. Late-stage functionalization of drugs and natural products were realized by means of this route. Data from density-functional-theory studies were in good agreement with experimental results.

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Organic Chemistry Frontiers
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