Medicinal chemistry of the myeloid C-type lectin receptors Mincle, Langerin, and DC-SIGN
Literature Information
Publication Date
2021-09-16
DOI
10.1039/D1MD00238D
Impact Factor
0
Authors
Jonathan Cramer
View Original
Abstract
In their role as pattern-recognition receptors on cells of the innate immune system, myeloid C-type lectin receptors (CLRs) assume important biological functions related to immunity, homeostasis, and cancer. As such, this family of receptors represents an appealing target for therapeutic interventions for modulating the outcome of many pathological processes, in particular related to infectious diseases. This review summarizes the current state of research into glycomimetic or drug-like small molecule ligands for the CLRs Mincle, Langerin, and DC-SIGN, which have potential therapeutic applications in vaccine research and anti-infective therapy.
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CAS Number:
1020174-04-2
Molecular Formula:
C10H17BN2O2
![5-Acetyl-2,3-dihydrobenzo[b]furan structure](https://static.chemtradehub.com/structs/908/90843-31-5-eea4.webp "5-Acetyl-2,3-dihydrobenzo[b]furan structure")
![1-Naphthalenesulfonic acid, 2-[(2-hydroxy-1-naphthalenyl)azo]-, bariumsalt (2:1) structure](https://static.chemtradehub.com/structs/110/1103-38-4-0b33.webp "1-Naphthalenesulfonic acid, 2-[(2-hydroxy-1-naphthalenyl)azo]-, bariumsalt (2:1) structure")
1-Naphthalenesulfonic acid, 2-[(2-hydroxy-1-naphthalenyl)azo]-, bariumsalt (2:1)
CAS Number:
1103-38-4
Molecular Formula:
C20H14BaN2O4S
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