Recent advances in hydride transfer-involved C(sp3)–H activation reactions

Literature Information

Publication Date 2021-01-07
DOI 10.1039/D0QO01502D
Impact Factor 5.281
Authors

Xiao-De An


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Abstract

The hydride transfer reaction, which is characterized by a redox-neutral and step/atom economic process, has emerged as an enabling platform for C(sp3)–H activation with high efficiency. During the past five years, significant advances have been made in new versions of hydride transfer-enabled C(sp3)–H activation, which mainly include the construction of novel scaffolds for cycles, and the intermolecular methods of both hydride transfer and C(sp3)–H functionalization. Herein, we summarize recent progress according to the reaction types categorized into hydride transfer/intramolecular C(sp3)–H functionalization, hydride transfer/intermolecular C(sp3)–H functionalization, and hydride reduction reactions. Furthermore, unsolved scientific problems as well as future directions in this field are also directly indicated. This review covers the period from 2016 to 2020.

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Organic Chemistry Frontiers

Organic Chemistry Frontiers
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Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

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