1-(5-Bromo-2-fluorophenyl)-2,2,2-trifluoroethanol
CAS Number:
1039827-16-1
Molecular Formula:
C8H5BrF4O
Diastereoselective construction of the benzannulated spiroketal core of chaetoquadrins enabled by a regiodivergent cascade
Literature Information
Publication Date
2020-05-26
DOI
10.1039/D0QO00484G
Impact Factor
5.281
Authors
Shengxiang Qiu, Hongxin Liu, Haibo Tan
View Original
Abstract
A remarkable acid-mediated methodology for the regiodivergent construction of a biologically interesting tricyclic benzannulated spiroketal skeleton with diastereomeric specificity was uncovered using a variety of readily available phenol substrates. The approach mainly refers to an intriguing hemi-ketalization/dehydration/Michael addition/ketalization cascade process, offering a viable synthetic strategy to efficiently access analogs of chaetoquadrins.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
(S)-(1,4-Dioxan-2-yl)methyl 4-methylbenzenesulfonate
CAS Number:
917882-64-5
Molecular Formula:
C12H16O5S
![{3-[Bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl}[4-(2-chlorophenyl)-1-piperazinyl]methanone structure](https://static.chemtradehub.com/structs/170/170365-25-0-e4d7.webp "{3-[Bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl}[4-(2-chlorophenyl)-1-piperazinyl]methanone structure")
{3-[Bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl}[4-(2-chlorophenyl)-1-piperazinyl]methanone
CAS Number:
170365-25-0
Molecular Formula:
C36H37ClN4O3
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