![2-Methyl-2-propanyl [2-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethyl]carbamate structure](https://static.chemtradehub.com/structs/141/1415562-38-7-c0a4.webp "2-Methyl-2-propanyl [2-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethyl]carbamate structure")
2-Methyl-2-propanyl [2-(2-oxa-6-azaspiro[3.3]hept-6-yl)ethyl]carbamate
CAS Number:
1415562-38-7
Molecular Formula:
C12H22N2O3
A covalently crosslinked silk fibroin hydrogel using enzymatic oxidation and chemoenzymatically synthesized copolypeptide crosslinkers consisting of a GPG tripeptide motif and tyrosine: control of gelation and resilience
Literature Information
Publication Date
2020-04-08
DOI
10.1039/D0PY00187B
Impact Factor
5.582
Authors
Hiromitsu Sogawa, Takuya Katashima, Keiji Numata
View Original
Abstract
A covalently crosslinked silk fibroin hydrogel (ChemSF) was successfully formed via an enzymatic crosslinking reaction using chemoenzymatically synthesized copolypeptides [poly(GPGn-r-Ym)], which consist of a glycine–proline–glycine (GPG) tripeptide motif and tyrosine (Y), as linker molecules. The gelation time of ChemSF was effectively shortened to less than 100 seconds without loss of toughness by adding poly(GPGn-r-Ym). In addition, the resilience of ChemSF was improved up to 86% at 66% strain, comparable to that of elastin, due to the flexible conformation of the poly(GPGn-r-Ym) crosslinker. The acceleration of the gelation and the improvement of the resilience of ChemSF were simultaneously achieved by using a multifunctional peptide crosslinker.
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Polymer Chemistry
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