Rh-Catalyzed C–H activation/intramolecular condensation for the construction of benzo[f]pyrazolo[1,5-a][1,3]diazepines
Literature Information
Publication Date
2020-03-20
DOI
10.1039/D0OB00382D
Impact Factor
3.876
Authors
Yi Ning, Xinwei He, Youpeng Zuo, Jian Wang, Qiang Tang, Mengqing Xie, Ruxue Li, Yongjia Shang
View Original
Abstract
A novel and mild Rh(III)-catalyzed C–H activation/intramolecular condensation of 1-aryl-1H-pyrazol-5-amines with cyclic 2-diazo-1,3-diketones was developed, giving access to various important benzo[f]pyrazolo[1,5-a][1,3]diazepine scaffolds through sequential C–C/C–N bond formation in a one-pot procedure under additive- and oxidant-free conditions. Furthermore, 3-([1,1′-biphenyl]-2-ylamino)-2-ethoxycyclohex-2-enones can be obtained in good yields by constructing C–O and C–N bonds through 1,1′-insertion, dehydration, and isomerization processes.
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Source Journal
Organic & Biomolecular Chemistry
CiteScore:
3.4
Self-citation Rate:
10.3%
Articles per Year:
1041
Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.
Recommended Compounds
2-Methyl-2-propanyl 3-benzyl-4-oxo-1-piperidinecarboxylate
CAS Number:
193274-82-7
Molecular Formula:
C17H23NO3
2-Methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline
CAS Number:
1609394-10-6
Molecular Formula:
C10H12N4O
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