![4-{[4-(Trifluoromethoxy)benzyl]oxy}benzonitrile structure](https://static.chemtradehub.com/structs/103/1036629-63-6-2172.webp "4-{[4-(Trifluoromethoxy)benzyl]oxy}benzonitrile structure")
4-{[4-(Trifluoromethoxy)benzyl]oxy}benzonitrile
CAS Number:
1036629-63-6
Molecular Formula:
C15H10F3NO2
Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands
Literature Information
Publication Date
2021-03-26
DOI
10.1039/D0MD00428F
Impact Factor
0
Authors
Tomris Coban, Cameron Robertson, Sianne Schwikkard, Richard Singer, Adam LeGresley
View Original
Abstract
The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes.
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Source Journal
Recommended Compounds
8-Methyl-2-pyridin-4-ylquinoline-4-carboxylic acid
CAS Number:
107027-42-9
Molecular Formula:
C16H12N2O2
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