Design, synthesis, and biological evaluation of pyrazole-linked aloe emodin derivatives as potential anticancer agents‡
Literature Information
Publication Date
2021-04-26
DOI
10.1039/D0MD00315H
Impact Factor
0
Authors
Bandi Siva, Sravanthi Vadlamudi, Surendar Reddy Bathula, Hashnu Dutta, K. Suresh Babu
View Original
Abstract
In connection with our continuous efforts to generate new derivatives from lead compounds isolated from traditional medicinal plants, a series of aloe-emodin derivatives (6a–6e) were synthesized and assessed for their potential anticancer activity against a panel of cancer cell lines. The results showed that most of the derivatives are more active than the aloe-emodin and particularly, 6b and 6e manifested potent activity with IC50 values of 1.32 & 1.6 μM and 0.99 & 2.68 μM against MDA-MB-231 and MCF-7 cells, respectively. Moreover, 6b and 6e induce early and late apoptosis as well as arrest the cell cycle at the G2/M phase in MDA-MB-231 cells. In conclusion, the results confirmed that the aloe-emodin derivatives could be a potential drug candidate for better treatment of breast cancer.
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