2-Methyl-2-propanyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate
CAS Number:
154026-93-4
Molecular Formula:
C10H19ClO4
Copper-catalyzed synthesis of trifluoromethylated bis(indolyl)arylmethanes from 2-arylindoles and 2,2,2-trifluoroacetohydrazide
Literature Information
Publication Date
2019-12-19
DOI
10.1039/C9QO01131E
Impact Factor
5.281
Authors
Zihang Yuan, Shouxiong Chen, Zhiqiang Weng
View Original
Abstract
One-pot synthesis of trifluoromethylated bis(indolyl)arylmethanes through copper-catalyzed reaction of 2-arylindoles with 2,2,2-trifluoroacetohydrazide is described. This viable transformation provides a variety of 3,3′-bis(indolyl)methanes with a CF3-containing tertiary carbon center in moderate to good yields. Preliminary mechanistic studies revealed that the reaction involves the in situ generation of a trifluoroacetyl radical and trapping with 2-arylindoles.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
Recommended Compounds
2-(2-Aminoethyl)-1H-isoindole-1,3(2H)-dione hydrochloride (1:1)
CAS Number:
30250-67-0
Molecular Formula:
C10H11ClN2O2
![N,N'-1,2-Ethanediylbis[2-(vinylsulfonyl)acetamide] structure](https://static.chemtradehub.com/structs/667/66710-66-5-b556.webp "N,N'-1,2-Ethanediylbis[2-(vinylsulfonyl)acetamide] structure")
N,N'-1,2-Ethanediylbis[2-(vinylsulfonyl)acetamide]
CAS Number:
66710-66-5
Molecular Formula:
C10H16N2O6S2
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