Catalyst-controlled selective mono-/dialkylation of 2-aryl-4(3H)-quinazolinones
Literature Information
Publication Date
2019-05-08
DOI
10.1039/C9QO00496C
Impact Factor
5.281
Authors
Yi Luo, Hua He, Jianglian Li, Xinling Yu, Mei Guan, Yong Wu
View Original
Abstract
Catalyst-controlled selective mono-/dialkylation of 2-aryl-4(3H)-quinazolinones with α-diazotized Meldrum's acid has been achieved successfully via a metal carbene migratory insertion process. With a Cp*Rh(III) catalyst, monoalkylation compounds are the predominant products while a Cp*Ir(III) catalyst selectively affords dialkylation products. Furthermore, these developed methods have good functional group tolerance with a low catalyst loading unprecedentedly.
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Source Journal
Organic Chemistry Frontiers
CiteScore:
7.8
Self-citation Rate:
8.7%
Articles per Year:
724
Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry
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(E)-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-2-ol
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581802-26-8
Molecular Formula:
C11H21BO3
5-(3,4-Dimethoxybenzyl)-2,4-pyrimidinediamine hydrochloride (1:1)
CAS Number:
2507-23-5
Molecular Formula:
C13H17ClN4O2
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