Highly efficient enantioselective synthesis of bispiro[benzofuran-oxindole-pyrrolidine]s through organocatalytic cycloaddition

Literature Information

Publication Date 2019-03-18
DOI 10.1039/C9QO00241C
Impact Factor 5.281
Authors

Boyu Li, Fengyun Gao, Xing Feng, Mengmeng Sun, Yifei Guo, Dongwa Wen, Yabo Deng, Jinqi Huang, Kairong Wang, Wenjin Yan


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Abstract

A series of compounds featuring novel bispiro[benzofuran-oxindole-pyrrolidine] moieties have been achieved through a thiourea-catalyzed 1,3-dipolar cycloaddition reaction. The Michael/Mannich reaction of N-2,2,2-trifluoroethylisatin ketimines with aurones furnished the cycloadducts in excellent yields with excellent stereoselectivities.

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Source Journal

Organic Chemistry Frontiers

Organic Chemistry Frontiers
CiteScore: 7.8
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Organic Chemistry Frontiers publishes high-quality research from across organic chemistry. Emphases are placed on studies that make significant contributions to the field of organic chemistry by reporting either new or significantly improved protocols or methodologies. Topics include, but are not limited to the following: Organic synthesis Development of synthetic methodologies Catalysis Natural products Functional organic materials Supramolecular and macromolecular chemistry Physical and computational organic chemistry

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