Nickel-catalyzed C–H bond trifluoromethylation of 8-aminoquinoline derivatives by acyl-directed functionalization
Literature Information
Publication Date
2019-02-27
DOI
10.1039/C9QO00173E
Impact Factor
5.281
Authors
Guijie Mao
View Original
Abstract
A Ni(TFA)2-catalyzed ortho-trifluoromethylation of 8-aminoquinoline derivatives was developed by acyl-directed C–H functionalization. A series of 7-trifluoromethylquinolinamine derivatives were originally obtained with moderate to excellent yields by using TMSCF3 as the trifluoromethylation reagent under mild conditions. In addition, the reaction mechanism is proposed and proved by the related experiment.
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Organic Chemistry Frontiers
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