![3-(6-Nitrobenzo[d][1,3]dioxol-5-yl)acrylic acid structure](https://static.chemtradehub.com/structs/631/6315-90-8-6b36.webp "3-(6-Nitrobenzo[d][1,3]dioxol-5-yl)acrylic acid structure")
Controlling release kinetics of pH-responsive polymer nanoparticles
Literature Information
Publication Date
2020-01-24
DOI
10.1039/C9PY01946D
Impact Factor
5.582
Authors
Naruphorn Dararatana, Farzad Seidi, Juliette Hamel, Daniel Crespy
View Original
Abstract
Polymers with pH-responsive properties are well-known in biomedical applications. We design here polymers that can release payloads upon acidification of their immediate environment. Various corrosion inhibitors such as benzotriazole-5-carbohydrazide, 5-(aminomethyl)-8-hydroxyquinoline, and tryptamine are conjugated to copolymers via imine or hydrazone linkages. Polymer-corrosion inhibitor conjugates displayed a faster release rate of the inhibitor under acidic conditions compared to neutral conditions. Release profiles were controlled by the type of the labile linkage, the nature of the corrosion inhibitor, and by the spacer length.
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Source Journal
Polymer Chemistry
CiteScore:
8.6
Self-citation Rate:
7.3%
Articles per Year:
457
Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
Recommended Compounds
![1,4-Piperazinediylbis{[6-(1H-benzimidazol-2-yl)-2-pyridinyl]methanone} structure](https://static.chemtradehub.com/structs/191/1912399-75-7-b9f0.webp "1,4-Piperazinediylbis{[6-(1H-benzimidazol-2-yl)-2-pyridinyl]methanone} structure")
1,4-Piperazinediylbis{[6-(1H-benzimidazol-2-yl)-2-pyridinyl]methanone}
CAS Number:
1912399-75-7
Molecular Formula:
C30H24N8O2
![3-({2-[(2R,4S)-4-Fluoro-2-methyl-1-pyrrolidinyl]-2-oxoethyl}amino)-3-methyl-1-(1-pyrrolidinyl)-1-butanone structure](https://static.chemtradehub.com/structs/118/1186426-66-3-b2e9.webp "3-({2-[(2R,4S)-4-Fluoro-2-methyl-1-pyrrolidinyl]-2-oxoethyl}amino)-3-methyl-1-(1-pyrrolidinyl)-1-butanone structure")
3-({2-[(2R,4S)-4-Fluoro-2-methyl-1-pyrrolidinyl]-2-oxoethyl}amino)-3-methyl-1-(1-pyrrolidinyl)-1-butanone
CAS Number:
1186426-66-3
Molecular Formula:
C16H28FN3O2
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