![[1-(5-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]methanol structure](https://static.chemtradehub.com/structs/143/1439822-99-7-6cc9.webp "[1-(5-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]methanol structure")
[1-(5-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]methanol
CAS Number:
1439822-99-7
Molecular Formula:
C10H11N3O
A radical cyclization cascade of 2-alkynylbenzonitriles with sodium arylsulfinates
Literature Information
Publication Date
2018-10-15
DOI
10.1039/C8OB02288G
Impact Factor
3.876
Authors
Bang Zhou, Wenqi Chen, Yuzhong Yang, Yuan Yang, Guobo Deng, Yun Liang
View Original
Abstract
A convenient radical cyclization cascade procedure for the construction of sulfonated indenones from 2-alkynylbenzonitriles and sodium arylsulfinates has been explored under mild reaction conditions. The present methodology offers a low-cost and operationally straightforward approach to synthesizing various sulfonated indenones in moderate to good yields by simple use of cheap sodium persulfate as an oxidant and environmentally benign water as a co-solvent.
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Source Journal
Organic & Biomolecular Chemistry
CiteScore:
3.4
Self-citation Rate:
10.3%
Articles per Year:
1041
Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.
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