Transmembrane H+/Cl− cotransport activity of bis(amido)imidazole receptors
Literature Information
Sopan Valiba Shinde, Pinaki Talukdar
A series of sickle-shaped bis(amido) imidazoles are synthesized for their ion transport studies. Proton–anion binding by the neutral and protonated form of receptors assessed by 1H-NMR titration experiments confirmed better chloride binding by the protonated form of a receptor compared to its neutral form. The transport experiments across unimolecular vesicles (by HPTS and lucigenin assays) confirmed the H+/Cl− symport process under the applied pH gradient conditions. The transporter also allows anion antiport as evident from the studies under symmetrical pH conditions. The ionophoric activity by the mobile carrier mechanism is proved by the U-tube experiment.
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Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry. We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products. Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal. More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.











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