A novel Mn–Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion

Literature Information

Publication Date 2019-10-02
DOI 10.1039/C9CC06040E
Impact Factor 6.222
Authors

Jiangli Fan, Wen Sun, Fahui Li, Kaoxue Li, Xishi Tai, Xiaojun Peng


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Abstract

A bimetallic complex, containing Mn(II) and Cu(II) moieties, was synthesized for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a hydroxyl radical (˙OH) via a Fenton-like reaction involving a Mn complex, and simultaneously depleting glutathione via a Cu complex induced oxidative reaction, thereby enhancing the efficiency of CDT.

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